Description

Pemigatinib CAS NO 1513857-77-6 is a potent and selective small-molecule inhibitor of fibroblast growth factor receptor (FGFR) isoforms 1, 2, and 3. This compound matters as a critical active pharmaceutical ingredient (API) for targeted cancer therapies, offering a mechanism to address tumors driven by FGFR genetic alterations. It is primarily needed by pharmaceutical manufacturers and advanced research institutions engaged in oncology drug development and clinical trials.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of targeted cancer therapeutics.
• Research and development of novel oncology treatments targeting FGFR pathways.
• Pre-clinical and clinical studies for cholangiocarcinoma and other solid tumors.
• Manufacturing of finished dosage forms, such as tablets, under GMP conditions.
• Biochemical research to study FGFR signaling and resistance mechanisms.
• Reference standard for analytical method development and quality control laboratories.

Basic Information

Product Name	Pemigatinib
CAS No.	1513857-77-6
Molecular Formula	C24H27N5O2
Molecular Weight	417.51 g/mol
Synonyms	INCB054828; Pemazyre (trade name); 1-((6-Amino-5-(trifluoromethyl)pyridin-3-yl)methyl)-3-(2,6-difluorobenzyl)-1,3,5-triazinane-2,4,6-trione; FGFR Inhibitor INCB054828; Pemigatinib (INCB054828); Pemigatinibum; UNII-0P6C3Z1775
EINECS	Contact for details

Quality Control

Our Pemigatinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.