Description

Vecabrutinib is a potent and selective small-molecule inhibitor targeting Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway. This targeted mechanism makes it a critical intermediate and active pharmaceutical ingredient (API) for advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of novel therapeutics for autoimmune disorders and B-cell malignancies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of finished drug products targeting BTK.
• Preclinical & Clinical Research: Used as a reference standard and active component in studies for autoimmune diseases like rheumatoid arthritis and lupus.
• Oncology Drug Development: Essential for research into treatments for B-cell cancers such as chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenström's macroglobulinemia.
• Biochemical Assay Development: Employed as a tool compound to study BTK inhibition kinetics and cellular signaling pathways in vitro.
• API Manufacturing: Used in the cGMP-compliant production of finished dosage forms for clinical trials and commercial supply.

Basic Information

Product Name	Vecabrutinib
CAS No.	1510829-06-7
Molecular Formula	C₂₇H₂₉N₅O₃
Molecular Weight	471.55 g/mol
Synonyms	SNS-062; (S)-5-Amino-1-(1-(but-2-ynoyl)pyrrolidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide; Vecabrutinib (SNS-062); (S)-5-Amino-3-(4-phenoxyphenyl)-1-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1H-pyrazole-4-carboxamide; BTK Inhibitor SNS-062; 1H-Pyrazole-4-carboxamide, 5-amino-1-[(3S)-1-(2-butynoyl)-3-pyrrolidinyl]-3-(4-phenoxyphenyl)-
EINECS	Contact for details

Quality Control

Our Vecabrutinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, confirming compliance with client specifications and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.