Description

Alisertib is a potent and selective small-molecule inhibitor of Aurora A kinase, a key regulator of cell cycle progression. This compound is of significant interest for its role in disrupting mitosis and inducing apoptosis in rapidly dividing cells, making it a valuable tool in oncology research and development. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on cancer therapeutics, targeted drug discovery, and preclinical studies.

Application

• Oncology Research & Drug Discovery: A critical reference standard and active pharmaceutical ingredient (API) in the development of novel anti-cancer therapies targeting Aurora kinases.
• Biochemical & Cell-Based Assays: Used as a selective inhibitor to study the biological function and signaling pathways of Aurora A kinase in vitro.
• Preclinical Studies: Employed in pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in animal models of various cancers.
• Mechanism of Action (MoA) Studies: Essential for investigating cell cycle arrest, mitotic spindle formation, and mechanisms of apoptosis.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex drug candidates or prodrugs.
• Quality Control & Analytical Testing: Used as a certified reference material (CRM) for HPLC, LC-MS, and NMR method development and validation in QC laboratories.

Basic Information

Product Name	Alisertib
CAS No.	1477482-19-1
Molecular Formula	C₂₇H₃₂N₆O₃
Molecular Weight	488.59 g/mol
Synonyms	MLN8237; (S)-1-(4-(4-((4-((3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl)methoxy)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)piperidin-1-yl)-2-hydroxypropan-1-one; Aurora A Kinase Inhibitor MLN8237; ALISERTIB (MLN8237); UNII-88U152P8LX
EINECS	Contact for details

Quality Control

Our Alisertib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, IR, MS), purity determination by HPLC, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.