Description

5-o-(4,4'-Dimethoxytrityl)-N4-Acetyl-5-Iodo-Deoxycytosine CAS NO 1472616-91-3 is a high-purity, protected nucleoside derivative specifically engineered for oligonucleotide synthesis and pharmaceutical research. This compound serves as a critical building block for the controlled introduction of modified cytosine bases into nucleic acid sequences, enabling advanced studies in antisense therapy, siRNA development, and molecular diagnostics. It is an essential raw material for biotechnology companies, CROs/CDMOs, and academic research institutions focused on next-generation therapeutic and diagnostic platforms.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate halogenated cytosine analogs to enhance binding affinity, stability, and therapeutic efficacy of oligonucleotide drugs.
• Molecular Diagnostics: Enables the creation of specialized probes and primers with unique hybridization properties for PCR and sequencing applications.
• Chemical Biology Research: A versatile intermediate for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• Pharmaceutical Intermediate: Serves as a protected synthon in the multi-step synthesis of novel nucleoside-based antiviral or anticancer agents.
• Bioconjugation & Labeling: The iodine moiety provides a handle for further functionalization via cross-coupling reactions for attachment of fluorophores or other reporter groups.

Basic Information

Product Name	5-o-(4,4'-Dimethoxytrityl)-N4-Acetyl-5-Iodo-Deoxycytosine
CAS No.	1472616-91-3
Molecular Formula	C34H34IN3O7
Molecular Weight	747.56 g/mol
Synonyms	5-Iodo-2'-deoxycytidine DMT protected; N4-Acetyl-5-iodo-2'-deoxycytidine, 5'-O-(4,4'-Dimethoxytrityl)-; 5-Iodo-dC(DMT)Ac; 5-I-2'-deoxycytidine derivative; 5-Iodo-2'-deoxycytidine, N4-acetyl-, 5'-O-bis(4-methoxyphenyl)phenylmethyl ether; DMTr-N4-Ac-5-I-dC; Protected 5-Iododeoxycytidine
EINECS	Contact for details

Quality Control

Our 5-o-(4,4'-Dimethoxytrityl)-N4-Acetyl-5-Iodo-Deoxycytosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of the biopharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent degradation due to moisture sensitivity. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and water ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.