Description

K-Ras Inhibitor CAS NO 1469338-01-9 is a potent and selective small molecule inhibitor targeting the Kirsten rat sarcoma viral oncogene homolog (K-Ras) protein, a key driver in various cancers. This compound is crucial for advancing oncology research and the development of targeted cancer therapies, particularly for tumors with K-Ras mutations. It is primarily needed by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on cancer biology, drug discovery, and preclinical studies.

Application

• Oncology Research & Drug Discovery: A critical tool for studying K-Ras signaling pathways, validating drug targets, and screening for novel anti-cancer compounds.
• Preclinical Development: Used in in vitro and in vivo models to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of K-Ras targeted therapies.
• Biochemical Assays: Serves as a reference standard and active agent in high-throughput screening (HTS) and enzymatic assays to measure K-Ras inhibition.
• Mechanistic Studies: Enables researchers to investigate the role of specific K-Ras mutations (e.g., G12C, G12D) in tumorigenesis and therapy resistance.
• Combination Therapy Research: Explored in studies assessing synergistic effects with other targeted agents, chemotherapy, or immunotherapy.

Basic Information

Product Name	K-Ras Inhibitor
CAS No.	1469338-01-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	K-Ras G12C Inhibitor; KRAS Inhibitor; ARS-853; 2-[(2S)-1-(4-Acetylpiperazin-1-yl)-1-oxopropan-2-yl]-N-[4-[(2S,3R)-3-ethyl-4-oxo-2-(2-oxo-1,3-oxazolidin-3-yl)-1,3-thiazolidin-5-ylidene]cyclohexa-2,5-dien-1-yl]acetamide; (S)-2-(4-Acetylpiperazine-1-carboxamido)-N-((S)-4-((R)-3-ethyl-4-oxo-2-(oxazolidin-2-on-3-yl)thiazolidin-5-ylidene)cyclohexa-2,5-dien-1-yl)propenamide; ARS853
EINECS	Contact for details

Quality Control

Our K-Ras Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research use. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.