Description

Adavivint is a potent and selective small molecule inhibitor of the Wnt/β-catenin signaling pathway, identified by its unique CAS number. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action, which is implicated in various disease states, including oncology and regenerative medicine. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in drug discovery and preclinical studies.

Application

• Oncology Research: Investigation as a potential therapeutic agent for cancers driven by aberrant Wnt/β-catenin signaling, such as colorectal, liver, and breast cancers.
• Stem Cell & Regenerative Medicine: Used in studies to modulate stem cell differentiation and proliferation for tissue engineering applications.
• Biochemical Pathway Analysis: Serves as a critical tool compound for elucidating the role of the Wnt pathway in cellular processes and disease models.
• High-Throughput Screening (HTS): Employed as a reference standard in assay development and validation for drug discovery campaigns.
• Academic Research: Fundamental research in developmental biology, cell fate determination, and signal transduction mechanisms.

Basic Information

Product Name	Adavivint
CAS No.	1467093-03-3
Molecular Formula	C₂₀H₁₈N₄O₃
Molecular Weight	362.38 g/mol
Synonyms	Adavivint; SM04690; Lorecivivint; Wnt/β-catenin pathway inhibitor SM04690; (S)-2-((2-(5-Chloro-2-methoxyphenyl)pyrimidin-4-yl)amino)-N-(5-fluoropyridin-2-yl)propanamide; 2-[[2-(5-Chloro-2-methoxyphenyl)pyrimidin-4-yl]amino]-N-(5-fluoropyridin-2-yl)propanamide
EINECS	Contact for details

Quality Control

Our Adavivint is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research purposes. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, MS) and purity assessment by HPLC. A Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.