Description

Tazemetostat Hydrobromide (Jan/Usan) is a high-purity, small molecule pharmaceutical ingredient classified as a potent and selective inhibitor of the EZH2 methyltransferase. This compound is of significant commercial and therapeutic interest for its targeted mechanism of action in oncology research and drug development. It is primarily utilized by pharmaceutical companies, biotechnology firms, and advanced research institutions engaged in the discovery and manufacturing of novel cancer therapeutics.

Application

• Oncology Drug Development: As the active pharmaceutical ingredient (API) in the formulation of targeted cancer therapies, specifically for conditions associated with EZH2 mutations.
• Preclinical & Clinical Research: For in vitro and in vivo studies investigating the role of EZH2 inhibition in various hematological malignancies and solid tumors.
• Reference Standard: Serves as a critical analytical standard for quality control and method development in pharmaceutical laboratories.
• Pharmaceutical Intermediates: Used in the synthesis and scale-up of finished dosage forms under current Good Manufacturing Practice (cGMP) environments.
• Biochemical Research: A key tool compound for epigenetic research, enabling the study of histone methylation and its impact on gene expression.

Basic Information

Product Name	Tazemetostat Hydrobromide (Jan/Usan)
CAS No.	1467052-75-0
Molecular Formula	C34H44N4O4 • HBr
Molecular Weight	645.66 g/mol (free base: 572.75 g/mol)
Synonyms	EPZ-6438 Hydrobromide; Tazverik (Brand Name API); EZH2 Inhibitor EPZ-6438 HBr; (R)-N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide Hydrobromide; UNII-1K5L8N5B6P; JAN/INN: Tazemetostat Hydrobromide
EINECS	Contact for details

Quality Control

Our Tazemetostat Hydrobromide is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with relevant regulatory frameworks for advanced intermediates and APIs. We adhere to a robust quality management system to guarantee batch-to-batch consistency and supply reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, in a cool, dry place. This material is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and potency. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.