Description

Lorlatinib CAS NO 1454846-35-5 is a potent, third-generation anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinase inhibitor. This compound is critical for advanced pharmaceutical research and development, particularly in the field of precision oncology. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of targeted cancer therapies for non-small cell lung cancer (NSCLC) and other malignancies.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of targeted cancer therapeutics.
• Reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research for next-generation ALK inhibitors.
• Biochemical tool for in vitro and in vivo pharmacological studies targeting ALK and ROS1 pathways.
• Use in preclinical and clinical trial material manufacturing for oncology applications.
• Critical reagent for drug metabolism and pharmacokinetics (DMPK) studies.

Basic Information

Product Name	Lorlatinib
CAS No.	1454846-35-5
Molecular Formula	C₂₁H₁₉FN₆O₂
Molecular Weight	406.42 g/mol
Synonyms	PF-06463922; Lorviqua; Lorlatinibum; (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile; Lorbrena
EINECS	Contact for details

Quality Control

Our Lorlatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.