Description

Siremadlin CAS NO 1448867-41-1 is a high-purity, small molecule pharmaceutical compound classified as an MDM2-p53 inhibitor. This compound is of significant interest for its targeted mechanism of action in disrupting the protein-protein interaction between MDM2 and the tumor suppressor p53, thereby reactivating p53-mediated pathways. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in oncology drug discovery and preclinical development.

Application

• Oncology Research & Drug Discovery: A key investigational agent for studying p53 reactivation pathways and developing novel cancer therapeutics.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and efficacy in various cancer models.
• Biochemical Assays: Serves as a reference standard and active pharmaceutical ingredient (API) in high-throughput screening and mechanism-of-action studies.
• Pharmaceutical Intermediates: Can be utilized in the synthesis and development of more complex therapeutic agents targeting the MDM2-p53 axis.

Basic Information

Product Name	Siremadlin
CAS No.	1448867-41-1
Molecular Formula	C31H39N5O4
Molecular Weight	545.67 g/mol
Synonyms	HDM201; NVP-HDM201; (S)-1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxopiperazin-1-yl)trans-cyclohexylmethyl]amino}phenyl)-1,4-dihydro-2H-isoquinolin-3-one; SAR405838; RG7388; MDM2 Inhibitor HD-M201; 1,4-Dihydro-2H-isoquinolin-3-one derivative HDM201
EINECS	Contact for details

Quality Control

Our Siremadlin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS). A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.