Description

Azd3965 CAS NO 1448671-31-5 is a potent and selective small molecule inhibitor of monocarboxylate transporter 1 (MCT1), a key target in oncology research. This compound is critical for investigating tumor metabolism and developing novel cancer therapeutics, as it disrupts lactate transport essential for cancer cell survival. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in preclinical cancer studies and drug discovery programs.

Application

• Oncology Research & Drug Discovery: A key pharmacological tool for studying the role of MCT1 in tumor metabolism, proliferation, and the tumor microenvironment.
• Preclinical Development: Used in in vitro and in vivo models to validate MCT1 as a therapeutic target and assess the efficacy of metabolic inhibition strategies.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize new MCT1 inhibitors.
• Mechanistic Studies: Employed to investigate lactate shuttle dynamics, pH regulation in cancer cells, and potential synergies with other anticancer agents.
• Academic Research: Fundamental research into metabolic pathways, cellular energetics, and the development of treatment resistance in various cancer types.

Basic Information

Product Name	Azd3965
CAS No.	1448671-31-5
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	AZD-3965; AZD 3965; 7-(3,5-Dimethyl-1H-pyrazol-4-yl)-3-(4-fluorophenyl)quinazoline-2,4(1H,3H)-dione; MCT1 Inhibitor AZD3965; Monocarboxylate Transporter 1 Inhibitor AZD3965; 7-(3,5-Dimethyl-1H-pyrazol-4-yl)-3-(4-fluorophenyl)-1,3-dihydro-2,4-quinazolinedione
EINECS	Contact for details

Quality Control

Our Azd3965 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable and reproducible results for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.