Description

[5-(Trifluoromethyl)Thiophen-3-Yl]Methanol CAS NO 1447913-56-5 is a high-value trifluoromethyl-substituted thiophene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a thiophene heterocycle with a trifluoromethyl group and a hydroxymethyl handle, provides exceptional versatility for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often improves metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its electron-withdrawing and coordinating properties.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the effects of fluorine substitution on molecular properties in academic and industrial R&D.

Basic Information

Product Name	[5-(Trifluoromethyl)Thiophen-3-Yl]Methanol
CAS No.	1447913-56-5
Molecular Formula	C6H5F3OS
Molecular Weight	182.16 g/mol
Synonyms	(5-(Trifluoromethyl)thiophen-3-yl)methanol; 3-(Hydroxymethyl)-5-(trifluoromethyl)thiophene; 5-(Trifluoromethyl)-3-thiophenemethanol; α-(5-Trifluoromethyl-3-thienyl)methanol; 3-Thiophenemethanol, 5-(trifluoromethyl)-; [5-(Trifluoromethyl)-3-thienyl]methanol
EINECS	Contact for details

Quality Control

Our [5-(Trifluoromethyl)Thiophen-3-Yl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.