Description

4',5'-Didehydro-5'-Deoxy-5-Methyluridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer agents, particularly in the development of nucleoside-based prodrugs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the creation of next-generation therapeutic molecules. The compound's unique structure allows for targeted modifications to enhance drug efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting viral polymerases for diseases such as hepatitis and herpes.
• Oncology Research: Serves as a scaffold for creating chemotherapeutic agents that interfere with DNA synthesis in rapidly dividing cells.
• Biochemical Tool: Employed in enzymatic studies to investigate substrate specificity and inhibition mechanisms of nucleoside kinases and other enzymes.
• Medicinal Chemistry: A valuable building block for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4',5'-Didehydro-5'-Deoxy-5-Methyluridine
CAS No.	1446748-33-9
Molecular Formula	C10H12N2O5
Molecular Weight	240.21 g/mol
Synonyms	5-Methyl-2'-deoxy-2',3'-didehydrouridine; 5-Methyldidehydrodeoxyuridine; 4',5'-Didehydro-5'-deoxy-5-methyluridine; 2'-Deoxy-2',3'-didehydro-5-methyluridine; 5-Methyl-2',3'-didehydro-2'-deoxyuridine; Didehydro-5-methyl-2'-deoxyuridine; 5-Methyl-D4U
EINECS	Contact for details

Quality Control

Our 4',5'-Didehydro-5'-Deoxy-5-Methyluridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.