Description

Enasidenib CAS NO 1446502-11-9 is a potent and selective small molecule inhibitor of the mutant isocitrate dehydrogenase 2 (IDH2) enzyme. This compound is of critical importance in the field of targeted cancer therapy, specifically for the treatment of relapsed or refractory acute myeloid leukemia (AML) with an IDH2 mutation. Pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology drug development require this high-purity active pharmaceutical ingredient (API) for formulation, clinical research, and commercial production.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of targeted cancer therapeutics.
• Oncology Research as a critical reference standard and tool compound for studying IDH2-mutant cancers.
• Preclinical and Clinical Development of new drug candidates and combination therapies for AML and other hematologic malignancies.
• Biochemical Assay Development for screening and profiling compounds targeting mutant IDH2 enzymes.
• Pharmacology Studies investigating the mechanisms of action, resistance, and metabolism of IDH2 inhibitors.

Basic Information

Product Name	Enasidenib
CAS No.	1446502-11-9
Molecular Formula	C19H17F6N3O2
Molecular Weight	433.35 g/mol
Synonyms	AG-221; CC-90007; IDHIFA® (brand name); 2-Methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol; (S)-2-Methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
EINECS	Contact for details

Quality Control

Our Enasidenib is manufactured under strict quality management systems to meet the rigorous standards required for pharmaceutical intermediates and APIs. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.