Description

Pamiparib is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor, specifically targeting PARP1 and PARP2 enzymes. This compound is of significant interest for its role in the research and development of targeted cancer therapies, particularly for tumors with homologous recombination deficiencies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Oncology Research: A key investigational agent for studying DNA damage response (DDR) pathways and synthetic lethality in cancer cells.
• Preclinical Development: Used in *in vitro* and *in vivo* models to evaluate efficacy against various cancer types, including ovarian, breast, and prostate cancers.
• Biomarker Studies: Employed in research to identify and validate predictive biomarkers for PARP inhibitor sensitivity.
• Combination Therapy Research: Investigated in combination with other therapeutic agents, such as chemotherapy or radiation, to enhance anti-tumor effects.
• Mechanism of Action Studies: A vital tool for elucidating the detailed molecular mechanisms of PARP inhibition and its downstream effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Pamiparib
CAS No.	1446261-44-4
Molecular Formula	C19H18FN5O
Molecular Weight	351.38 g/mol
Synonyms	BGB-290; (S)-2-(2-Fluoro-4-(piperazin-1-yl)phenyl)-1H-benzo[d]imidazole-4-carboxamide; Pamiparib maleate; BGB 290; UNII-9J97361Y2H
EINECS	Contact for details

Quality Control

Our Pamiparib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.