Description

N6-Benzoyl-9-(2'-Deoxy-2'-Fluoro-B-D-Arabinofuranosyl)Adenine is a high-purity nucleoside analog building block designed for advanced pharmaceutical research and development. This compound is critical for the synthesis of modified oligonucleotides, particularly in the development of antisense and siRNA therapeutics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, high-quality intermediates for nucleic acid chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antisense Oligonucleotide (ASO) Synthesis: Used in the solid-phase or solution-phase synthesis of fluorinated arabinonucleic acid (FANA) oligonucleotides for therapeutic applications.
• siRNA and RNA Therapeutics: Serves as a modified nucleoside precursor to enhance the stability, specificity, and pharmacokinetic properties of RNA-based drugs.
• Proteomics & Genomics Research: Employed as a specialized reagent in academic and industrial research exploring gene function and regulation.
• Diagnostic Probe Development: Utilized in creating labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic techniques.
• Process Development & Scale-Up: Supports process chemistry teams in scaling up the production of active pharmaceutical ingredients (APIs) containing modified nucleosides.

Basic Information

Product Name	N6-Benzoyl-9-(2'-Deoxy-2'-Fluoro-B-D-Arabinofuranosyl)Adenine
CAS No.	1446113-65-0
Molecular Formula	C23H21FN6O5
Molecular Weight	480.45 g/mol
Synonyms	2'-Fluoro-2'-deoxy-β-D-arabinofuranosyl-N6-benzoyladenine; 2'-F-ara-N6-Bz-Adenine; 9-[(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)]-N6-benzoyladenine; 2'-F-Arabinofuranosyl Adenine, N6-Benzoyl-; N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine; 2'-Fluoro-araA(N-Bz); Bz-2'F-araA; 1446113-65-0
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-9-(2'-Deoxy-2'-Fluoro-B-D-Arabinofuranosyl)Adenine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.