Description

Belvarafenib is a potent and selective small-molecule inhibitor of the RAF kinase family, specifically designed to target oncogenic mutations. This compound is of significant interest in the field of precision oncology for its potential to address resistance mechanisms in certain cancer pathways. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in the discovery and development of targeted cancer therapies.

Application

• Oncology Research & Drug Discovery: As a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for RAF-dependent cancers.
• Mechanistic Studies: For investigating signal transduction pathways, particularly the MAPK/ERK pathway, and understanding drug resistance mechanisms.
• Biochemical Assay Development: Used as a critical tool compound in high-throughput screening (HTS) and enzyme inhibition assays.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of novel drug candidates or prodrugs targeting kinase activity.
• Clinical Trial Material (CTM): Supplied under GMP conditions for use in formulating investigational new drugs for clinical trials.

Basic Information

Product Name	Belvarafenib
CAS No.	1446113-23-0
Molecular Formula	C₂₉H₂₈F₃N₅O₃
Molecular Weight	551.56 g/mol
Synonyms	Belvarafenib; N-(3-(5-Chloro-2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-fluoro-4-methylbenzamide; ARRY-162; RG-6185; BVD-523; 1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, N-[3-(5-chloro-2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-fluoro-4-methyl-; ARRY 162; RG 6185
EINECS	Contact for details

Quality Control

Our Belvarafenib is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under inert atmosphere (e.g., nitrogen) after opening to minimize moisture uptake and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.