Description

Jak3-In-6 is a potent and selective small-molecule inhibitor of the Janus kinase 3 (JAK3) enzyme, a key target in immunology and oncology research. This high-purity compound is essential for scientists investigating JAK-STAT signaling pathways and developing novel therapeutics for autoimmune diseases and cancer. It is a critical research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on inflammation, immune regulation, and hematological malignancies.

Application

• Biochemical Research: Used as a selective tool compound to study JAK3-specific signaling mechanisms and pathway inhibition in cellular assays.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the screening and optimization of new JAK3-targeted therapeutic agents.
• Immunology Studies: Applied in vitro to investigate the role of JAK3 in T-cell and NK-cell function, aiding research into autoimmune conditions like rheumatoid arthritis and psoriasis.
• Oncology Research: Utilized to explore the therapeutic potential of JAK3 inhibition in hematologic cancers and other malignancies driven by JAK-STAT activation.
• Cellular Pathway Analysis: Enables precise dissection of the JAK-STAT pathway's contribution to cell proliferation, apoptosis, and immune response.

Basic Information

Product Name	Jak3-In-6
CAS No.	1443235-95-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	JAK3-IN-6; (S)-N-(3-(4-(2-(2,6-Dichloro-3,5-dimethoxyphenyl)amino)pyrimidin-4-yl)-1H-pyrazol-1-yl)phenyl)acrylamide; 1443235-95-7; JAK3 Inhibitor-6; JAK3i-6; Tofacitinib analog; JAK3 selective inhibitor
EINECS	Contact for details

Quality Control

Every batch of Jak3-In-6 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and mass spectrometry. Our quality commitment supports research reproducibility and compliance with global standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.