Description

Ripretinib CAS NO 1442472-39-0 is a potent and selective small-molecule kinase inhibitor specifically designed to target KIT and PDGFRA mutations. This compound is of critical importance in the pharmaceutical industry for the development of targeted cancer therapies. It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for advanced systemic mastocytosis and gastrointestinal stromal tumors (GIST).

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of targeted oncology drugs.
• Key intermediate for advanced pharmaceutical research and development programs.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Biochemical research tool for studying kinase inhibition pathways and mechanisms of action.
• Pre-clinical and clinical trial material for novel cancer therapy formulations.

Basic Information

Product Name	Ripretinib
CAS No.	1442472-39-0
Molecular Formula	C30H33F2N7O2
Molecular Weight	561.62 g/mol
Synonyms	DCC-2618; TAK-580; Ripretinib (DCC-2618); 1H-Pyrrolo[2,3-b]pyridine, 3-[(1R)-1-[2,6-dichloro-3-fluorophenyl]ethoxy]-5-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-; (R)-3-((1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-1H-pyrrolo[2,3-b]pyridine; Qinlock (brand name)
EINECS	Contact for details

Quality Control

Our Ripretinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.