Description

Cb-839 CAS NO 1439399-58-2 is a potent and selective small molecule inhibitor of glutaminase 1 (GLS1), a key enzyme in cellular metabolism. This compound is of significant interest for its role in disrupting glutamine metabolism, a pathway critical for the proliferation of certain cancer cells. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and metabolic disease for preclinical and clinical-stage therapeutic development.

Application

• Oncology Research: Investigation as a targeted therapeutic agent for glutamine-addicted tumors, including triple-negative breast cancer, pancreatic cancer, and acute myeloid leukemia.
• Drug Discovery & Development: Serving as a critical pharmacological tool and lead compound in the development of novel anti-cancer therapies.
• Biochemical Research: Used in in vitro and in vivo studies to elucidate the role of glutaminase in cell signaling, metabolism, and tumor biology.
• Combination Therapy Studies: Evaluation in conjunction with other chemotherapeutic agents or immunotherapies to assess synergistic effects.
• Metabolic Disorder Research: Exploration of its effects in diseases where altered glutamine metabolism is implicated.

Basic Information

Product Name	Cb-839
CAS No.	1439399-58-2
Molecular Formula	C₁₇H₁₈F₂N₄O₃
Molecular Weight	364.35 g/mol
Synonyms	Telaglenastat; CB 839; CB-839; (2S)-2-[[4-[2-(2,3-Difluorophenyl)acetyl]-1-piperazinyl]carbonyl]-3-methylbutanoic acid; GLS1 Inhibitor CB-839; Glutaminase Inhibitor CB-839; UNII-4Z3U4P6J4T
EINECS	Contact for details

Quality Control

Our Cb-839 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS for identity confirmation and purity assessment. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.