Description

Gdc-0853 CAS NO 1434048-34-6 is a high-purity, small molecule compound belonging to the class of kinase inhibitors. This compound is critical for pharmaceutical research and development, particularly in the study of targeted cancer therapies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel oncology therapeutics.
• Biochemical Assays: Used as a potent and selective inhibitor in enzymatic and cellular assays to study specific kinase pathways and their role in disease mechanisms.
• Preclinical Studies: Essential for in vitro and in vivo pharmacological evaluation to establish proof-of-concept, efficacy, and pharmacokinetic profiles.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) campaigns to identify and validate new drug candidates targeting similar pathways.
• Mechanism of Action (MoA) Studies: A vital tool for researchers to elucidate the detailed biological mechanisms and signaling cascades involved in specific cancers.
• Chemical Biology: Used as a molecular probe to investigate protein function and interactions within complex biological systems.

Basic Information

Product Name	Gdc-0853
CAS No.	1434048-34-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GDC-0853; GDC 0853; 1434048-34-6; Fenebrutinib; (S)-2-(4-(4-Amino-3-(3-fluoro-5-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-cyclopropyl-1-(4-(methylsulfonyl)phenyl)propan-1-one; RO-5503781; RG-7841
EINECS	Contact for details

Quality Control

Our Gdc-0853 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.