Description

4-Chloro-3,5-Difluorobenzenemethanol is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly within the pharmaceutical and agrochemical sectors. Industries requiring precise chemical modifications, such as medicinal chemistry research and specialty chemical manufacturing, need this material for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the chlorodifluorobenzene structure imparts specific biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display and lighting technologies.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer chains, enhancing material properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: The benzylic alcohol and halogen substituents make it a valuable substrate in Suzuki, Heck, and other palladium-catalyzed coupling reactions.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex aromatic and heterocyclic compounds.

Basic Information

Item	Detail
Product Name	4-Chloro-3,5-Difluorobenzenemethanol
CAS No.	1431329-58-6
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	(4-Chloro-3,5-difluorophenyl)methanol; 4-Chloro-3,5-difluorobenzyl alcohol; 3,5-Difluoro-4-chlorobenzenemethanol; 4-Chloro-3,5-difluorophenylmethanol; 4-Chloro-3,5-difluorobenzyl alcohol; α-Hydroxy-4-chloro-3,5-difluorotoluene; Benzenemethanol, 4-chloro-3,5-difluoro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorobenzenemethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.