Description

Poziotinib (HM 781-36B) is a potent, irreversible tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) family. This compound is of significant interest for its potential in oncology research and targeted cancer therapy development. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in the discovery of novel treatments for non-small cell lung cancer (NSCLC) and other solid tumors.

Application

• Oncology Research: A key investigational agent for studying resistance mechanisms and developing new therapeutic strategies against EGFR-mutant cancers, particularly NSCLC.
• Biochemical Assay Development: Used as a reference standard or active pharmaceutical ingredient (API) in the development of high-throughput screening assays and potency tests.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicology profiles.
• Pharmaceutical Intermediates: Serves as a critical intermediate or building block in the synthesis of more complex drug candidates or for structure-activity relationship (SAR) studies.
• Reference Standard: Provides a certified material for analytical method validation, quality control, and regulatory submissions.

Basic Information

Product Name	Poziotinib (HM 781-36B)
CAS No.	1429757-68-5
Molecular Formula	C26H27N5O3
Molecular Weight	457.53 g/mol
Synonyms	HM 781-36B; HM781-36B; HM78136B; Poziotinib; (E)-N-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide; NOV120101
EINECS	Contact for details

Quality Control

Our Poziotinib (HM 781-36B) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.