Description

Tucatinib (Hemiethanolate) CAS NO 1429755-56-5 is a potent and selective small-molecule tyrosine kinase inhibitor (TKI) targeting HER2. This compound is of critical importance in the development of targeted cancer therapies, particularly for HER2-positive breast and colorectal cancers. It is primarily required by pharmaceutical R&D departments, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for use in clinical research, formulation development, and commercial drug production.

Application

• Primary active pharmaceutical ingredient (API) in targeted oncology therapeutics.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Key intermediate in advanced research on HER2-driven cancer pathways and drug resistance mechanisms.
• Biochemical tool for in vitro and in vivo pharmacological studies and preclinical testing.
• Material for formulation development of solid oral dosage forms (e.g., tablets).

Basic Information

Product Name	Tucatinib (Hemiethanolate)
CAS No.	1429755-56-5
Molecular Formula	C₂₆H₂₄N₈O₂ • 0.5C₂H₆O
Molecular Weight	480.53 g/mol (free base: 450.52)
Synonyms	Tucatinib ethanolate; Tucatinib hemialcoholate; ARRY-380; ONT-380; Irbinitinib; N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide hemialcoholate; (E)-N-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide hemialcoholate
EINECS	Contact for details

Quality Control

Our Tucatinib (Hemiethanolate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed HPLC purity, related substances, residual solvents, and other critical parameters are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.