Description

Mutant Idh1-In-2 is a potent and selective small molecule inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme. This compound is a critical research tool for investigating the role of mutant IDH1 in cancer metabolism and tumorigenesis, particularly in gliomas and acute myeloid leukemia (AML). It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and metabolic pathway analysis.

Application

• Oncology Research: Used as a reference standard and pharmacological tool to study the effects of mutant IDH1 inhibition in cellular and animal models of cancer.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the synthesis and screening of novel targeted cancer therapies.
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzymatic assays to identify and characterize new inhibitors of the mutant IDH1 pathway.
• Mechanistic Studies: Facilitates research into the oncometabolite 2-hydroxyglutarate (2-HG) and its role in epigenetic dysregulation and cellular differentiation.
• Preclinical Evaluation: Critical for evaluating pharmacokinetics, pharmacodynamics, and efficacy in preclinical studies for potential anticancer agents.

Basic Information

Product Name	Mutant Idh1-In-2
CAS No.	1429176-69-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IDH1 Inhibitor; Mutant IDH1 Inhibitor; AGI-5198 analog; Isocitrate Dehydrogenase 1 (IDH1) Mutant Inhibitor; (R)-Enantiomer of AGI-5198; Research Compound 1429176-69-1; IDH1-R132H Inhibitor; Oncometabolite Pathway Inhibitor
EINECS	Contact for details

Quality Control

Our Mutant Idh1-In-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity consistent with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, potency, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider storing under an inert atmosphere. Allow the product to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.