Description

5-Aminomethyl-2',3'-Di-o-Isopropylidene 2-Thiouridine is a sophisticated, protected nucleoside derivative designed for advanced synthetic chemistry. This compound is a critical building block in the synthesis of modified oligonucleotides, enabling the precise introduction of thio-modifications into nucleic acid sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic oligonucleotides, antisense agents, and diagnostic probes.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of thio-modified RNA and DNA strands.
• Antisense & RNA Therapeutics: Used to create oligonucleotides with enhanced nuclease resistance and binding affinity for target mRNA sequences.
• Structural Biology Studies: Incorporation into nucleic acids to study RNA structure, folding, and protein-RNA interactions via thiol-specific labeling or crosslinking.
• Diagnostic Probe Development: Enables the production of high-specificity probes for genetic testing and molecular diagnostics.
• Medicinal Chemistry Research: Serves as an intermediate in the discovery and optimization of novel nucleoside-based antiviral or anticancer agents.
• Bioconjugation: The aminomethyl group provides a handle for further functionalization and conjugation with reporter molecules or delivery vehicles.

Basic Information

Product Name	5-Aminomethyl-2',3'-Di-o-Isopropylidene 2-Thiouridine
CAS No.	1428903-07-4
Molecular Formula	C17H25N3O5S
Molecular Weight	383.46 g/mol
Synonyms	5-(Aminomethyl)-2',3'-O-isopropylidene-2-thiouridine; 2-Thio-5-aminomethyluridine isopropylidene derivative; 2',3'-O-Isopropylidene-5-(aminomethyl)-2-thiouridine; 5-(Aminomethyl)-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidene-pyrimidin-4-one; Protected 2-Thiouridine Aminomethyl Derivative; 2-Thio-5-NH2CH2-uridine acetonide
EINECS	Contact for details

Quality Control

Every batch of 5-Aminomethyl-2',3'-Di-o-Isopropylidene 2-Thiouridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, critical for sensitive oligonucleotide synthesis. Our quality system ensures compliance with relevant standards for fine chemicals. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.