Description

Baxdrostat CAS NO 1428652-17-8 is a potent and selective small-molecule inhibitor of aldosterone synthase (CYP11B2), a key enzyme in the renin-angiotensin-aldosterone system. This compound is of significant interest for its potential therapeutic application in treating conditions associated with aldosterone excess, such as resistant hypertension and primary aldosteronism. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in cardiovascular and endocrine disease research.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for hypertension and hyperaldosteronism.
• Mechanistic Studies: For investigating the physiological and pathological roles of aldosterone and the CYP11B2 enzyme in laboratory settings.
• Drug Discovery Programs: Serving as a lead compound or pharmacologic tool in the development of novel antihypertensive agents.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and enzymatic assays to identify and characterize new CYP11B2 inhibitors.
• Academic Research: Employed in university and institutional labs for cardiovascular and renal pathophysiology research.
• Metabolism and Toxicology Studies: For profiling metabolic pathways, pharmacokinetics, and safety of aldosterone synthase inhibitors.

Basic Information

Item	Detail
Product Name	Baxdrostat
CAS No.	1428652-17-8
Molecular Formula	C23H21F3N4O3
Molecular Weight	458.44 g/mol
Synonyms	CIN-107; CIN107; Baxdrostat Hydrochloride; (S)-4-(3-Cyclopropyl-1H-pyrazol-5-yl)-2-fluoro-N-(1-(2-fluorobenzyl)-5-(methylcarbamoyl)-1H-pyrazol-3-yl)benzamide; Aldosterone Synthase Inhibitor CIN-107; CYP11B2 Inhibitor
EINECS	Contact for details

Quality Control

Our Baxdrostat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.