Description

Parsaclisib is a potent, selective, and orally bioavailable inhibitor of phosphatidylinositol 3-kinase delta (PI3Kδ), a key signaling node in the immune system and certain cancers. This targeted mechanism of action makes it a critical research tool and a promising candidate for therapeutic development in oncology and immunology. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on hematologic malignancies, solid tumors, and inflammatory diseases.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the preclinical and clinical development of novel PI3Kδ-targeted therapies.
• Oncology Studies: Used in in vitro and in vivo research to investigate its efficacy against B-cell malignancies such as non-Hodgkin lymphoma, chronic lymphocytic leukemia (CLL), and other hematologic cancers.
• Immunology & Autoimmune Disease Research: Employed to study the role of PI3Kδ in immune cell function and to explore potential treatments for autoimmune and inflammatory conditions.
• Biochemical Assay Development: Acts as a critical control compound in high-throughput screening (HTS) and enzymatic assays to discover and validate new PI3Kδ inhibitors.
• Mechanism of Action (MoA) Studies: Essential for elucidating downstream signaling pathways and resistance mechanisms associated with PI3Kδ inhibition.
• GMP-Grade Manufacturing: High-purity grades support the cGMP-compliant manufacturing of drug substances for clinical trial materials.

Basic Information

Product Name	Parsaclisib
CAS No.	1426698-88-5
Molecular Formula	C23H24N8O
Molecular Weight	428.49 g/mol
Synonyms	INCB050465; INCB-050465; INCB 050465; 2-((1R,4s)-4-((4-((3-(2-Aminopropan-2-yl)-1H-indazol-5-yl)oxy)quinazolin-2-yl)amino)cyclohexyl)propan-2-ol; (1R,4s)-4-[[4-[[3-(2-Amino-2-methylpropyl)-1H-indazol-5-yl]oxy]-2-quinazolinyl]amino]cyclohexanemethanol; Parsaclisibum; UNII-5JX6V6L3PJ
EINECS	Contact for details

Quality Control

Our Parsaclisib is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and comprehensive residual solvent and impurity profiling. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development standards. Specifications can be tailored to meet specific project requirements, including GMP-grade needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	<20 ppm
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.