Description

Seclidemstat is a potent and selective small-molecule inhibitor of the lysine-specific demethylase 1 (LSD1/KDM1A), a key epigenetic regulator. This compound is of significant interest for its role in modulating gene expression and cellular differentiation pathways. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and hematology for preclinical and clinical-stage drug discovery programs. Seclidemstat CAS NO 1423715-37-0 represents a critical tool for investigating novel therapeutic strategies targeting LSD1-dependent diseases.

Application

• Oncology Research: Investigation as a potential therapeutic agent for acute myeloid leukemia (AML), small cell lung cancer (SCLC), and other LSD1-dependent cancers.
• Hematology Drug Development: Targeting LSD1 in myelodysplastic syndromes (MDS) and other blood disorders.
• Epigenetics Studies: Used as a research chemical to study the role of histone demethylation in gene regulation and cellular identity.
• Preclinical Candidate: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel epigenetic therapies.
• Biochemical Assays: Employed as a reference standard or inhibitor in high-throughput screening and enzymatic activity assays.
• Combination Therapy Research: Exploration of synergistic effects with other chemotherapeutic or targeted agents.

Basic Information

Product Name	Seclidemstat
CAS No.	1423715-37-0
Molecular Formula	C₂₀H₂₀F₃N₅O₂
Molecular Weight	419.40 g/mol
Synonyms	SP-2577; CC-90011; (R)-N1-((6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)methyl)-N2-(1-(5-fluoropyridin-2-yl)ethyl)oxalamide; Seclidemstat mesylate; LSD1 Inhibitor SP-2577; KDM1A Inhibitor CC-90011; Seclidemstat (CC-90011)
EINECS	Contact for details

Quality Control

Our Seclidemstat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards. We support our clients with the documentation necessary for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.