Description

Azd-9291 CAS NO 1421373-65-0 is a high-purity, small molecule pharmaceutical intermediate and research chemical of significant commercial and scientific interest. This compound is valued for its critical role in the development and synthesis of targeted oncology therapies. It is primarily utilized by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, targeted cancer therapeutics.
• Oncology Research: Used as a reference standard and active material in biochemical and cellular assays for studying specific kinase inhibition pathways.
• Drug Discovery & Development: Serves as a crucial precursor in medicinal chemistry programs for optimizing drug candidates.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for active pharmaceutical ingredients (APIs).
• Analytical Standard: Provides a high-purity benchmark for quality control (QC) and analytical method development in pharmaceutical production.
• Preclinical Studies: Utilized in formulation development and pharmacokinetic/pharmacodynamic (PK/PD) research.

Basic Information

Product Name	Azd-9291
CAS No.	1421373-65-0
Molecular Formula	C₂₈H₃₃N₇O₂
Molecular Weight	499.61 g/mol
Synonyms	Osimertinib; Osimertinib Mesylate Intermediate; AZD-9291; AZD9291; N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide; Tagrisso Intermediate; Mereletinib
EINECS	Contact for details

Quality Control

Our Azd-9291 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity against established reference standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.