Description

Mutant Egfr Inhibitor CAS NO 1421373-62-7 is a potent and selective small molecule compound designed to target and inhibit specific mutant forms of the Epidermal Growth Factor Receptor (EGFR), a key protein implicated in various cancers. This precision-targeted inhibitor is crucial for advancing oncology research and the development of next-generation therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on targeted cancer therapies and drug discovery programs.

Application

• Oncology Research & Drug Discovery: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the development of targeted cancer therapies.
• Biochemical Assay Development: Used as a key reagent in high-throughput screening (HTS) and in vitro assays to study EGFR mutant signaling pathways.
• Mechanism of Action (MOA) Studies: Essential for investigating resistance mechanisms and the efficacy of combination treatments in preclinical models.
• Pharmaceutical Intermediate: Employed in the synthesis of more complex drug candidates or prodrugs targeting EGFR mutations.
• Academic & Clinical Research: Supports fundamental research into cell proliferation, apoptosis, and tumor biology related to EGFR-driven cancers.

Basic Information

Product Name	Mutant Egfr Inhibitor
CAS No.	1421373-62-7
Molecular Formula	C24H25ClFN5O2
Molecular Weight	477.94 g/mol
Synonyms	Osimertinib; AZD9291; Mereletinib; (E)-N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; Tagrisso (Trade Name); EGFR T790M Inhibitor; Third-generation EGFR Tyrosine Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Mutant Egfr Inhibitor is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material supporting pre-clinical and pharmaceutical development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.