Description

Benzenemethanol, 4-Amino-3-(Trifluoromethyl)- is a high-value trifluoromethylated benzylamine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a benzyl alcohol group adjacent to a trifluoromethyl substituent, makes it a versatile intermediate for creating compounds with enhanced biological activity and physicochemical properties. This compound is essential for research and development in the pharmaceutical and agrochemical sectors, where it is used to synthesize novel active ingredients. Its application extends to materials science for the development of specialty polymers and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides that leverage the trifluoromethyl group for improved efficacy and environmental profile.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel chiral ligands and catalysts for asymmetric synthesis.
• Functional Material Precursor: Intermediate in the production of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Serves as a reactive handle for bioconjugation and the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Benzenemethanol, 4-Amino-3-(Trifluoromethyl)-
CAS No.	1416372-95-6
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	4-Amino-3-(trifluoromethyl)benzyl alcohol; 3-(Trifluoromethyl)-4-aminobenzyl alcohol; (4-Amino-3-(trifluoromethyl)phenyl)methanol; 4-(Aminomethyl)-2-(trifluoromethyl)phenol (tautomer); 4-Amino-α-(trifluoromethyl)benzenemethanol; 2-Trifluoromethyl-4-aminobenzyl alcohol; 4-Amino-3-trifluoromethylbenzenemethanol
EINECS	Contact for details

Quality Control

Our Benzenemethanol, 4-Amino-3-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.