Description

Pf 02341066 Hydrochloride is a high-purity, research-grade small-molecule inhibitor with confirmed activity against specific kinase targets in preclinical oncology and immunology studies. It serves as a critical tool compound for target validation, mechanism-of-action studies, and lead optimization in pharmaceutical R&D pipelines. This material is essential for biotechnology companies, contract research organizations (CROs), and academic laboratories engaged in drug discovery and translational medicine programs.

Application

• Preclinical target engagement studies in kinase-driven cancer models
• In vitro pharmacodynamic profiling of selective inhibition kinetics
• Reference standard for bioanalytical method development (LC-MS/MS, HPLC)
• Lead compound in structure–activity relationship (SAR) campaigns
• Cell-based assay calibration for phospho-protein signaling pathway analysis
• Formulation stability testing under accelerated conditions
• Crystallization trials for structural biology (X-ray crystallography)
• Metabolite identification studies using human liver microsomes

Basic Information

Product Name	Pf 02341066 Hydrochloride
CAS No.	1415560-69-8
Molecular Formula	C22H26ClN5O3·HCl
Molecular Weight	476.40 g/mol
Synonyms	Pf-02341066 hydrochloride; PF-02341066 HCl; Crizotinib hydrochloride; (R)-3-[(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)methyl]-5-(1-piperidinyl)isoxazole-4-carboxamide hydrochloride; NSC-759424 hydrochloride; CHEMBL2104177; UNII-07QZV3Y7FJ; Crizotinib HCl; (R)-Crizotinib hydrochloride
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q5A–Q5E guidelines for identity, purity, assay, residual solvents, and heavy metals. Testing includes HPLC purity ≥ 99.5%, water content by Karl Fischer ≤ 0.5%, and residual palladium ≤ 5 ppm. Compliant with ISO 9001:2015 and cGMP-aligned manufacturing practices.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay	99.0–101.0% (as-is basis)
Related Substances (HPLC)	Any single impurity ≤ 0.1%; Total impurities ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.