Description

(S)-3,3-Difluoro-Cyclopentanemethanol is a chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the combination of a stereodefined cyclopentane scaffold with fluorine atoms and a hydroxymethyl handle, enabling precise modulation of molecular properties. This compound is primarily needed by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, where its unique structure can influence bioavailability, metabolic stability, and target binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in therapeutic areas requiring stereochemical precision.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorinated cyclopentane core can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential building block for specialty polymers and liquid crystals, leveraging its rigid, fluorinated structure.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of gem-difluoro substitution on ring conformation and reactivity.

Basic Information

Product Name	(S)-3,3-Difluoro-Cyclopentanemethanol
CAS No.	1407991-23-4
Molecular Formula	C6H10F2O
Molecular Weight	136.14 g/mol
Synonyms	(S)-3,3-Difluorocyclopentylmethanol; (1S)-3,3-Difluorocyclopentylmethanol; (S)-(3,3-Difluorocyclopentyl)methanol; (S)-3,3-Difluorocyclopentanemethanol; Cyclopentanemethanol, 3,3-difluoro-, (1S)-; (S)-3,3-Difluoro-1-hydroxymethylcyclopentane; (S)-α-(3,3-Difluorocyclopentyl)methanol
EINECS	Contact for details

Quality Control

Our (S)-3,3-Difluoro-Cyclopentanemethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.