Description

Pneumocandin B0, 1-[(4R,5S)-5-[(2-Aminoethyl)Amino]-N2-[(10R,12S)-10,12-Dimethyl-1-Oxotetradecyl]-4-Hydroxy-L-Ornithine]- is a key lipopeptide intermediate in the synthesis of advanced echinocandin antifungal agents. This compound is critical for pharmaceutical R&D and manufacturing, serving as the foundational scaffold for developing potent drugs targeting serious fungal infections. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development and production of novel antifungal therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the semi-synthetic production of echinocandin-class antifungal drugs, such as caspofungin.
• Antifungal Drug Research: Serves as a key starting material or reference standard in the discovery and development of new antifungal compounds targeting β-(1,3)-D-glucan synthase.
• Process Chemistry & Scale-Up: Used in process development and optimization studies for the commercial manufacturing of echinocandin APIs.
• Analytical Reference Standard: Employed as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.
• Biochemical Studies: Utilized in mechanistic studies to understand the interaction between echinocandins and their enzymatic target.

Basic Information

Product Name	Pneumocandin B0, 1-[(4R,5S)-5-[(2-Aminoethyl)Amino]-N2-[(10R,12S)-10,12-Dimethyl-1-Oxotetradecyl]-4-Hydroxy-L-Ornithine]-
CAS No.	1404083-47-1
Molecular Formula	C52H91N7O15
Molecular Weight	1054.3 g/mol
Synonyms	Pneumocandin B0; (4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine-1-Pneumocandin B0; Caspofungin Intermediate; Echinocandin B0 Derivative; L-Ornithine, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-; Antifungal Lipopeptide Intermediate
EINECS	Contact for details

Quality Control

Our Pneumocandin B0 is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including HPLC purity assay, identification by IR and MS, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual unknown impurity ≤ 1.0% Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.