Description

trans-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanemethanol is a high-value, protected cyclobutane derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound serves as a crucial advanced pharmaceutical intermediate (API) and a versatile chiral building block in sophisticated organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures, particularly in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of new drug candidates, especially those targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the rigid cyclobutane scaffold can impart unique biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with tailored thermal and mechanical properties.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale manufacturing of complex organic molecules.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions of strained systems.

Basic Information

Product Name	trans-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanemethanol
CAS No.	1403767-02-1
Molecular Formula	C12H26O2Si
Molecular Weight	230.42 g/mol
Synonyms	trans-3-((tert-Butyldimethylsilyl)oxy)cyclobutanemethanol; (1r,3r)-3-((tert-Butyldimethylsilyl)oxy)cyclobutanemethanol; (trans)-3-[(tert-Butyldimethylsilyl)oxy]cyclobutanemethanol; TBDMS-protected trans-3-hydroxycyclobutanemethanol; Cyclobutanemethanol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, trans-; (1R,3R)-3-[(tert-Butyldimethylsilyl)oxy]cyclobutane-1-methanol
EINECS	Contact for details

Quality Control

Our trans-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanemethanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.