Description

Tazemetostat (EPZ-6438) is a potent, selective, and orally bioavailable small molecule inhibitor of the histone-lysine N-methyltransferase EZH2 (Enhancer of Zeste Homolog 2). This compound matters as a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies, particularly for cancers driven by EZH2 gain-of-function mutations. It is needed by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on oncology, epigenetics, and drug discovery.

Application

• Pharmaceutical Research & Development: As a reference standard and key intermediate in the synthesis of targeted cancer therapeutics.
• Oncology Studies: For in vitro and in vivo research into the role of EZH2 in cancers such as non-Hodgkin lymphoma, malignant rhabdoid tumors, and synovial sarcoma.
• Epigenetics Research: A vital tool for investigating histone methylation and gene silencing mechanisms in cellular models.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and enzyme inhibition assays to identify and characterize novel EZH2 inhibitors.
• Preclinical Development: Serves as an active pharmaceutical ingredient (API) in formulation studies for oral dosage forms.
• Mechanism of Action (MoA) Studies: To understand and validate the downstream effects of EZH2 inhibition on tumor cell proliferation and apoptosis.

Basic Information

Product Name	Tazemetostat (EPZ-6438)
CAS No.	1403254-99-8
Molecular Formula	C34H44N4O4
Molecular Weight	572.74 g/mol
Synonyms	EPZ-6438; EPZ6438; Tazemetostat hydrobromide (unspecified salt form reference); N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; EZH2 Inhibitor EPZ-6438; EZH2 histone methyltransferase inhibitor EPZ-6438
EINECS	Contact for details

Quality Control

Our Tazemetostat (EPZ-6438) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.