Description

4-Chloro-3-[[(2S,3R)-2-(4-Chlorophenyl)-4,4,4-Trifluoro-3-Methyl-1-Oxobutyl]Amino]-Cyclopropyl-(S)-Benzenepropanoic Acid is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and metabolic disease. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable supply of sophisticated building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements.
• Drug Discovery & Development: Used in medicinal chemistry for lead optimization and the creation of targeted molecular libraries.
• Protease Inhibitor Research: Serves as a core structural motif in the development of enzyme inhibitors due to its specific amino acid-like linkage.
• Chemical Biology Probes: Employed in the design of molecular probes for studying biological pathways and target engagement.
• Process Chemistry: Scalable intermediate for the GMP production of candidate drugs during clinical trial material manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis.

Basic Information

Product Name	4-Chloro-3-[[(2S,3R)-2-(4-Chlorophenyl)-4,4,4-Trifluoro-3-Methyl-1-Oxobutyl]Amino]-Cyclopropyl-(S)-Benzenepropanoic Acid
CAS No.	1402936-61-1
Molecular Formula	C23H21Cl2F3NO3
Molecular Weight	478.32 g/mol
Synonyms	(S)-3-(4-Chloro-3-(((2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methyl-1-oxobutan-1-yl)amino)cyclopropyl)propanoic acid; (2S,3R)-2-(4-Chlorophenyl)-4,4,4-trifluoro-3-methyl-1-((S)-3-(3-carboxypropyl)-4-chlorocyclopropyl)aminobutan-1-one; 4-Chloro-3-[[(2S,3R)-2-(4-Chlorophenyl)-4,4,4-trifluoro-3-methyl-1-oxobutyl]amino]cyclopropyl-(S)-benzenepropanoic acid; CAS 1402936-61-1; Advanced trifluoromethylated cyclopropyl intermediate; Chiral cyclopropane amino acid derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral assay, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development projects with custom purity grades and can align with GMP guidelines for advanced phase manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.