Description

(R)-n-(tert-Butyl)Dimethylsilyl-S-Difluoromethyl-S-Phenylsulfoximine, Ee: 99% is a high-purity, chiral sulfoximine building block of significant interest in advanced organic synthesis. This compound is valued for its role as a versatile intermediate in the development of pharmaceuticals and agrochemicals, where its stereochemistry and unique functional groups enable precise molecular construction. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethyl and sulfoximine motifs can impart desirable biological activity and metabolic stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a precursor for developing chiral ligands or catalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry, exploring new C-H functionalization and fluorination reactions.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique properties.

Basic Information

Product Name	(R)-n-(tert-Butyl)Dimethylsilyl-S-Difluoromethyl-S-Phenylsulfoximine, Ee: 99%
CAS No.	1402352-49-1
Molecular Formula	C₁₃H₂₁F₂NOSSi
Molecular Weight	305.46 g/mol
Synonyms	(R)-N-[(1,1-Dimethylethyl)dimethylsilyl]-S-(difluoromethyl)-S-phenylsulfoximine; (R)-N-(tert-Butyldimethylsilyl)-S-(difluoromethyl)-S-phenylsulfoximine; (R)-TBDMS-Difluoromethyl-Phenylsulfoximine; (R)-S-Difluoromethyl-S-phenyl-N-(tert-butyldimethylsilyl)sulfoximine; (R)-N-(tert-Butyl)dimethylsilyl-S-difluoromethyl-S-phenylsulfoximine; (R)-Sulfoximine TBDMS derivative
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure a consistent enantiomeric excess of 99%. Quality is verified using advanced analytical techniques including chiral HPLC, ¹H/¹⁹F/¹³C NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each batch to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.