Description

Copanlisib is a potent and selective small-molecule inhibitor of phosphatidylinositol 3-kinase (PI3K), specifically targeting the p110α and p110δ isoforms. This compound matters as a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies, particularly in hematological malignancies and solid tumors. It is essential for pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) engaged in oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of the active pharmaceutical ingredient (API) for targeted cancer therapeutics.
• Oncology Research: Used as a reference standard and biochemical tool to study PI3K signaling pathways, tumor cell proliferation, and apoptosis.
• Preclinical Development: Employed in in vitro and in vivo studies to evaluate the efficacy and pharmacokinetics of PI3K inhibition.
• Biomarker Discovery: Aids in research to identify predictive biomarkers for patient response to PI3K-targeted therapies.
• Combination Therapy Studies: Investigated in research settings for potential synergistic effects with other anticancer agents like chemotherapy or immunotherapy.
• Reference Material: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Copanlisib
CAS No.	1402152-13-9
Molecular Formula	C23H28FN5O3
Molecular Weight	441.50 g/mol
Synonyms	BAY 80-6946; Aliqopa (trade name); 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; Copanlisib dihydrochloride (salt form); PI3K inhibitor BAY 80-6946; UNII-711U77U2AJ
EINECS	Contact for details

Quality Control

Our Copanlisib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, MS) to ensure it meets high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.