Description

Senaparib is a potent and selective small-molecule inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, a key target class in oncology research. This compound is critical for advancing the development of novel cancer therapeutics, particularly for tumors with deficiencies in DNA repair pathways such as BRCA mutations. It is an essential research-grade chemical for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in cancer biology studies, drug discovery programs, and preclinical development of targeted oncology agents.

Application

• Oncology Research & Drug Discovery: Primary tool compound for investigating the role of PARP inhibition in cancer cell lines and animal models.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize new PARP inhibitors.
• Mechanistic Studies: Enables research into synthetic lethality, DNA damage response (DDR) pathways, and combination therapy strategies.
• Preclinical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the formulation and testing of potential new drug candidates.
• Pharmacology & Toxicology Studies: Utilized to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles, and to assess safety margins in non-clinical models.

Basic Information

Item	Details
Product Name	Senaparib
CAS No.	1401682-78-7
Molecular Formula	C19H21FN6O2
Molecular Weight	384.41 g/mol
Synonyms	IMP4297; IMP-4297; (S)-2-Fluoro-5-((4-((4-morpholinophenyl)amino)-5H-pyrrolo[3,4-d]pyrimidin-6-yl)methyl)morpholine; Senaparib (IMP4297); 6-(((2S)-2-Fluoro-4-morpholinyl)methyl)-N-(4-morpholinophenyl)-5H-pyrrolo[3,4-d]pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our Senaparib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable for research chemicals, ensuring traceability and reliability for your critical development work.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.