Description

Amg 925 is a high-purity, small molecule chemical compound identified by CAS NO 1401033-86-0. This product is valued for its role as a potent and selective dual inhibitor of FGF receptor (FGFR) and FLT3 kinases, making it a critical research tool and potential intermediate in pharmaceutical development. It is primarily needed by researchers and manufacturers in the fields of oncology drug discovery, biochemical research, and the development of targeted cancer therapies.

Application

• Oncology Research & Drug Discovery: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel targeted cancer therapies.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and in vitro studies to investigate FGFR and FLT3 signaling pathways.
• Preclinical Studies: Employed in cellular and animal model research to evaluate the efficacy and mechanism of action of kinase inhibitors.
• Pharmaceutical Synthesis: Serves as a crucial building block or intermediate in the multi-step synthesis of more complex therapeutic candidates.
• Academic Research: Utilized in university and institutional labs for fundamental studies on tyrosine kinase function and cancer biology.

Basic Information

Item	Details
Product Name	Amg 925
CAS No.	1401033-86-0
Molecular Formula	C₂₃H₂₀F₃N₅O₂
Molecular Weight	455.43 g/mol
Synonyms	AMG-925; AMG 925; UNII-9P3H8B2A4S; 9P3H8B2A4S; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(2,6-dichlorophenyl)-N-[(1R)-1-(5-methyl-1H-pyrazol-3-yl)ethyl]-; (R)-1-(2,6-Dichlorophenyl)-N-(1-(5-methyl-1H-pyrazol-3-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; Dual FGFR/FLT3 Inhibitor (AMG-925)
EINECS	Contact for details

Quality Control

Our Amg 925 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing the specific results for identity, purity, and impurities is provided with every shipment to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.