Description

(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is a high-value, multifunctional boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value lies in the combination of a protected boronic acid functionality and a benzylic alcohol group, enabling versatile cross-coupling and subsequent functionalization reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for Suzuki-Miyaura cross-coupling reactions to create biaryl structures common in drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom and boronate group impart desirable biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and OFETs, where the boronate ester facilitates the formation of conjugated polymers and small molecules.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes, leveraging the reactivity of the boronic ester for bioconjugation.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Item	Details
Product Name	(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol
CAS No.	1400755-06-7
Molecular Formula	C13H18BFO3
Molecular Weight	252.09 g/mol
Synonyms	[3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol; (3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol; 3-Fluoro-5-(hydroxymethyl)phenylboronic acid pinacol ester; (3-Fluoro-5-(hydroxymethyl)phenyl)boronic acid pinacol ester; 5-(Hydroxymethyl)-3-fluorophenylboronic acid pinacol ester; Pinacol [3-fluoro-5-(hydroxymethyl)phenyl]boronate; CAS 1400755-06-7
EINECS	Contact for details

Quality Control

Our production of (3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.