Description

Milademetan CAS NO 1398568-47-2 is a potent and selective small molecule inhibitor of the MDM2-p53 protein-protein interaction. This compound is of significant interest in pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the discovery and development of novel cancer therapeutics targeting the p53 pathway.

Application

• Oncological Research: As a key investigational compound for studying the reactivation of the p53 tumor suppressor pathway in various cancer cell lines and models.
• Preclinical Drug Development: Serving as a lead candidate or reference standard in the development of MDM2 inhibitors for targeted cancer therapy.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro assays to evaluate MDM2 binding affinity and inhibitory activity.
• Pharmacology Studies: For investigating pharmacokinetics, pharmacodynamics, and efficacy in animal models of cancer.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical compounds.
• Mechanism of Action Studies: A critical tool for understanding apoptosis induction and cell cycle arrest mechanisms in p53-wildtype cancers.

Basic Information

Product Name	Milademetan
CAS No.	1398568-47-2
Molecular Formula	C30H30N4O4S
Molecular Weight	542.65 g/mol
Synonyms	DS-3032b; DS 3032; DS3032; Milademetan tosylate; RAIN-32; (R)-4-((3-(3-Chloro-2-fluorophenyl)-1-(2,4-dimethoxybenzyl)-6-methoxy-2-oxo-1,2-dihydroquinolin-4-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; 4-[(3R)-3-(3-Chloro-2-fluorophenyl)-1-[(2,4-dimethoxyphenyl)methyl]-6-methoxy-2-oxo-4-quinolyl]amino-3-methoxy-N-(1-methyl-4-piperidyl)benzamide
EINECS	Contact for details

Quality Control

Our Milademetan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.