Description

Ningetinib Tosylate CAS NO 1394820-77-9 is a potent and selective small molecule inhibitor targeting specific kinase pathways involved in cellular signaling. This compound is of significant value in pharmaceutical research and development, particularly for advancing novel therapeutic agents. It is primarily required by research institutions, pharmaceutical companies, and biotechnology firms engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of targeted cancer therapies.
• Biochemical Research: Used as a potent tool compound for studying kinase inhibition, signal transduction pathways, and mechanisms of action in cellular models.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicology profiles of drug candidates.
• Analytical Method Development: Acts as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods for quality control.

Basic Information

Product Name	Ningetinib Tosylate
CAS No.	1394820-77-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ningetinib Tosylate Salt; Ningetinib p-Toluenesulfonate; 1394820-77-9; UNII-8Q2R8I8K5T; Ningetinib tosylate (JPAN); (3Z)-3-[(3,5-Difluoro-4-{[(1r,4r)-4-(4-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl)cyclohexyl]oxy}phenyl)methylidene]-1,3-dihydro-2H-indol-2-one 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our Ningetinib Tosylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), residual solvents, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.