Description

Ningetinib is a potent and selective small molecule inhibitor primarily targeting the c-Met (mesenchymal-epithelial transition factor) receptor tyrosine kinase. This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications. It is utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel anti-cancer therapies.
• Preclinical Studies: Used in in vitro and in vivo models to investigate efficacy, pharmacokinetics, and mechanism of action against c-Met-dependent cancers.
• Biochemical Assays: Employed as a selective inhibitor in high-throughput screening and enzymatic assays to study c-Met signaling pathways.
• Drug Discovery Programs: A critical intermediate or target molecule for medicinal chemistry optimization and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Ningetinib
CAS No.	1394820-69-9
Molecular Formula	C₂₈H₂₈N₆O₃
Molecular Weight	496.56 g/mol
Synonyms	Ningetinib; TQ-B3395; (R)-1-(4-(4-((3-Fluoro-2-methoxyphenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)pyridin-2-yl)-N-methylpyrrolidine-3-carboxamide; TQ B3395; TQB3395; UNII-9Q2K0F2T1F; 9Q2K0F2T1F
EINECS	Contact for details

Quality Control

Our Ningetinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.