Description

4-Bromo-2-(Chloromethyl)-1-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromo, chloromethyl, and trifluoromethoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethoxy group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the halogenated benzene core for potent biological activity.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals for displays, and advanced organic electronic materials due to its ability to modify electronic properties and molecular conformation.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), enabling rapid diversification of the molecular scaffold.
• Nucleophilic Substitution Site: The reactive chloromethyl group serves as a versatile site for further functionalization with various nucleophiles, such as amines, alcohols, and thiols, to create more complex structures.
• Fluorine Chemistry Research: Serves as a valuable substrate in medicinal and agrochemical chemistry research to study the effects of the trifluoromethoxy group on physicochemical and biological properties.

Basic Information

Product Name	4-Bromo-2-(Chloromethyl)-1-(Trifluoromethoxy)Benzene
CAS No.	1393442-60-8
Molecular Formula	C8H5BrClF3O
Molecular Weight	289.48 g/mol
Synonyms	1-Bromo-4-(chloromethyl)-2-(trifluoromethoxy)benzene; 2-(Chloromethyl)-4-bromo-1-(trifluoromethoxy)benzene; 4-Bromo-2-(chloromethyl)-1-(trifluoromethoxy)benzene; 4-Bromo-2-chloromethyl-1-trifluoromethoxybenzene; Benzene, 4-bromo-2-(chloromethyl)-1-(trifluoromethoxy)-; (4-Bromo-2-(chloromethyl)phenyl) trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-2-(Chloromethyl)-1-(Trifluoromethoxy)Benzene adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay purity and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical applications and meet the rigorous standards required for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.