Description

Verdinexor (KPT-335) is a potent, orally bioavailable, and selective inhibitor of the nuclear export protein Exportin 1 (XPO1/CRM1). This small molecule compound is a critical research tool and a promising therapeutic candidate for its role in forcing the nuclear retention and activation of tumor suppressor proteins. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, virology, and autoimmune disease research.

Application

• Oncology Research: Investigated as a therapeutic agent in preclinical and clinical studies for various cancers, including hematological malignancies (e.g., AML, lymphoma) and solid tumors.
• Antiviral Research: Studied for its potential to inhibit the replication of viruses, such as influenza and HIV, by blocking the nuclear export of viral components.
• Autoimmune & Inflammatory Disease Models: Used in research to modulate immune responses by affecting the nuclear export of key inflammatory transcription factors.
• Mechanistic Biology Studies: A key pharmacological tool for studying XPO1-mediated nuclear export pathways and cellular signaling in disease models.
• Drug Combination Studies: Employed in research to evaluate synergistic effects with other chemotherapeutic or targeted agents.
• Biomarker Discovery: Used in research to identify and validate biomarkers associated with XPO1 inhibition and treatment response.

Basic Information

Product Name	Verdinexor (KPT-335)
CAS No.	1392136-43-4
Molecular Formula	C₁₇H₁₁F₃N₄O₂
Molecular Weight	360.29 g/mol
Synonyms	KPT-335; Verdinexor; Selinexor analog; (Z)-3-((3,5-Bis(trifluoromethyl)phenyl)amino)-N'-(2-methyl-1H-indol-5-yl)-2-(pyridin-4-yl)acrylohydrazide; CRM1 Inhibitor KPT-335; XPO1 Inhibitor KPT-335; Selective Inhibitor of Nuclear Export (SINE) compound
EINECS	Contact for details

Quality Control

Our Verdinexor (KPT-335) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.