Description

Erlotinib CAS NO 1384975-87-4 is a potent and selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical active pharmaceutical ingredient (API) in targeted cancer therapy, specifically designed to interfere with the signaling pathways that drive tumor cell proliferation and survival. It is essential for pharmaceutical manufacturers and research institutions developing treatments for non-small cell lung cancer (NSCLC) and pancreatic cancer.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulated anti-cancer medications, specifically tyrosine kinase inhibitor drugs.
• Oncology Research: A key reference standard and tool compound for in vitro and in vivo studies of EGFR signaling pathways and mechanisms of drug resistance.
• Drug Development: Used in preclinical and clinical development stages for novel targeted cancer therapies and combination treatment regimens.
• Generic Drug Manufacturing: Sourcing of high-purity API for the production of generic versions of EGFR inhibitor medications following patent expiry.
• Biochemical Assay Development: Serves as a critical control in high-throughput screening assays to discover new oncology targets or synergistic compounds.

Basic Information

Product Name	Erlotinib
CAS No.	1384975-87-4
Molecular Formula	C22H23N3O4
Molecular Weight	393.44 g/mol
Synonyms	Erlotinib Hydrochloride; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; CP-358774; OSI-774; Tarceva (Brand Name); NSC 718781; EGFR Tyrosine Kinase Inhibitor; 6,7-Bis(2-methoxyethoxy)quinazolin-4-yl-(3-ethynylphenyl)amine
EINECS	Contact for details

Quality Control

Our Erlotinib is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Each batch undergoes comprehensive analytical testing including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and rigorous control of specified impurities and residual solvents. A comprehensive Certificate of Analysis (COA) is provided, documenting compliance with in-house specifications aligned with ICH Q3 and pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.