Description

Ldk-378 Dihydrochloride is a high-purity chemical compound of significant interest in advanced research and development. This compound serves as a critical intermediate and building block in the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis pathway for novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used as a building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Research: Employed in the study of biological pathways and the development of enzyme inhibitors or receptor modulators.
• Fine Chemical Synthesis: Serves as a precursor in the multi-step synthesis of complex, high-value specialty chemicals.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploratory chemical research and the development of new synthetic methodologies.

Basic Information

Product Name	Ldk-378 Dihydrochloride
CAS No.	1380575-43-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LDK-378 dihydrochloride; LDK378 dihydrochloride; Ceritinib dihydrochloride (related compound); 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperazin-1-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine dihydrochloride; Zykadia intermediate; Novartis LDK-378 di-HCl; Research Compound 1380575-43-8
EINECS	Contact for details

Quality Control

Our Ldk-378 Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications and results for parameters including assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring high standards in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) or as indicated on the specific product label or COA.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.