Description

2,3-o-(1-Methylethylidene)-6-Thio-5-Inosinic Acid Bis(1,1-Dimethylethyl) Ester is a high-purity, protected nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the creation of novel nucleotide analogs and prodrugs, enabling precise chemical modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapeutics, and other targeted nucleotide-based medicines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside and nucleotide analogs for therapeutic applications.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor in the design of anticancer agents that interfere with DNA/RNA synthesis in tumor cells.
• Biochemical Research: Employed in studies of enzyme kinetics, nucleotide metabolism, and as a substrate analog for various biochemical assays.
• Prodrug Development: The protecting groups (isopropylidene and tert-butyl) make it a valuable intermediate for creating lipophilic, bioavailable prodrug forms of active nucleotides.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2,3-o-(1-Methylethylidene)-6-Thio-5-Inosinic Acid Bis(1,1-Dimethylethyl) Ester
CAS No.	1375103-71-1
Molecular Formula	C22H34N4O7S
Molecular Weight	498.60 g/mol
Synonyms	6-Thioinosine 5'-(bis(tert-butyl) phosphate) 2',3'-O-isopropylidene acetal; 2',3'-O-Isopropylidene-6-thioinosine 5'-(bis(tert-butyl) phosphate); 6-Thio-IMP bis(tert-butyl) ester 2',3'-acetonide; 6-Mercaptoinosine 5'-diphosphate bis(tert-butyl) ester, 2',3'-O-(1-methylethylidene) derivative; Protected 6-thioinosine monophosphate; 6-Thio-IMP(Bu-t)2 acetonide; 2',3'-O-Isopropylidene-6-thioinosine-5'-yl bis(tert-butyl) phosphate
EINECS	Contact for details

Quality Control

Our 2,3-o-(1-Methylethylidene)-6-Thio-5-Inosinic Acid Bis(1,1-Dimethylethyl) Ester is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C to maximize stability. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.